Publications

Neuroal Plasticity

Peptides Acting as Cognitive Enhancers

The aim of this paper is to present an overview of three peptides that, by improving synaptic function, enhance learning and memory in laboratory rodents. We summarize their structure, their mechanisms of action, and their effects on synaptic and cognitive function. First we describe FGL, a peptide...

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Trends in Neuroscience

PTEN: Local and Global Modulation of Neuronal Function in Health and Disease

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) controls neuronal growth and synaptic function not only during embryonic and postnatal development but also throughout adult life. Direct recruitment of PTEN to the postsynaptic membrane drives synaptic depression. PTEN's action at...

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Nature Neuroscience

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

Dyshomeostasis of amyloid-β peptide (Aβ) is responsible for synaptic malfunctions leading to cognitive deficits ranging from mild impairment to full-blown dementia in Alzheimer's disease. Aβ appears to skew synaptic plasticity events toward depression. We found that inhibition of PTEN, a...

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Hippocampus

A diet enriched with plant sterols prevents the memory impairment induced by cholesterol loss in senescence-accelerated mice

Cholesterol reduction at the neuronal plasma membrane has been related to age-dependent cognitive decline. We have used senescent-accelerated mice strain 8 (SAMP8), an animal model for aging, to examine the association between cholesterol loss and cognitive impairment and to test strategies to...

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Elsevier

Chapter 1 - What is Cognitive Enhancement?

“Cognitive enhancement” is commonly associated with drug use or the use of devices to improve cognition, technologies that have on the whole been established in laboratory animals or through a history of use in humans. In this chapter we aim to clarify the concept underlying “cognitive...

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Elsevier

Chapter 3 - Molecular Mechanisms of Drug-Induced Cognitive Enhancement

The concept of improving cognitive performance is particularly enticing, not just to ameliorate mental illness or slow-down physiological cognitive decline with aging, but also to enhance our natural cognitive abilities. There has been considerable progress in understanding the neuronal mechanisms...

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Elsevier

Chapter 9 - Alzheimer’s Disease and Mechanism-Based Attempts to Enhance Cognition

Alzheimer's disease (AD) is the leading neurodegenerative disease worldwide and the expected rise in patient numbers is a critical threat to our health care systems. Current treatment strategies are of limited efficacy and only transiently active. Thus, there is an urgent need for a better...

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Neural Plasticity

Spines, Plasticity, and Cognition in Alzheimer's Model Mice

The pathological hallmarks of Alzheimer's disease (AD)—widespread synaptic and neuronal loss and the pathological accumulation of amyloid-beta peptide (Aβ) in senile plaques, as well as hyperphosphorylated tau in neurofibrillary tangles—have been known for many decades, but the links between...

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The Journal of Neuroscience

Microscale AMPAR Reorganization and Dynamics of the Postsynaptic Density

AMPA-type receptors (AMPARs) are glutamate-gated channels whose postsynaptic activation convey the major depolarization in brain excitatory neurotransmission. Trafficking of these receptors to and from synapses is tightly regulated in neurons and underlies long-lasting forms of synaptic plasticity....

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