A new article in PloS Biology: Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement
Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals.
The pathological hallmarks of Alzheimer’s disease (AD)—widespread synaptic and neuronal loss and the pathological accumulation of amyloid-beta peptide (Aβ) in senile plaques, as well as hyperphosphorylated tau in neurofibrillary tangles—have been known for many decades, but the links between AD pathology and dementia and effective therapeutic strategies remain elusive.
A new journal club article in Journal of Neuroscience: Microscale AMPAR reorganization and dynamics of the postsynaptic density
AMPA-type receptors (AMPARs) are glutamate-gated channels whose postsynaptic activation convey the major depolarization in brain excitatory neurotransmission.
Cell growth and differentiation in developing tissues are, at first impression, quite different endeavors from readjusting synaptic strength during activity-dependent synaptic plasticity in mature neurons. Nevertheless, it is becoming increasingly clear that these two distinct processes share multiple intracellular signaling events. How these common pathways result in cell division (during
Our New book on Cognitive Enhancement
This new book contains a vast amount of information regarding traditional and modern strategies aimed at enhancing cognitive function, both in animals and humans. The editors made an effort to make this book accessible to the general public, although some of the chapters may be more scientifically orientated than others. Nevertheless, the general goal of this book is to bring together the bulk of information available in this field, in the hope that this will eventually help scientists to develop new, more efficient approaches to treat cognitive impairment.