We use a multielectrode array to record the activity of thousands of neurons simultaneously.
We use super-resolution confocal imaging and state-of-the-art software of image analysis, such as Imaris, Neurolucida and Neuroinfo.
Most of our studies involve a thorough behavioral analysis. For this purpose, our laboratory uses several tests that allow us to evaluate a wide range of rodent behaviors (Barnes Maze, Fear Conditioning, Novel Object Location, and more).
We treat rodents with a variety of drugs to examine their effect on cognition and behavior.
We use many electrophysiological techniques to study the biology of cognition. Specifically, we use patch-clamp and field recording as our main techniques.
We study signaling pathways involved in synaptic and cognitive functions
We use different strategies to manipulate the function of molecules in the brain, including pharmacology and gene transfer with viral vectors or plasmids in vitro and in vivo. We also use several lines of transgenic mice.
We use intracellular injections of fluorescent dyes (Lucifer Yellow, Alexa 594) in fixed tissue and in certain cases also injection of Biocytine during Patch Clamp recording.
We use viral vectors to express specific proteins in neurons in order to change learning and memory in rodents. This approach allowד us to understand the function of key brain proteins.
