Approaches

Our laboratory uses a multidisciplinary approach to study cognition at multiple levels of analyses.

Electrophysiology

We use many electrophysiological techniques to study the biology of cognition. Specifically, we use patch-clamp and field recording as our main techniques.

Electrophysiology

Multielectrode array

We use a multielectrode array to record the activity of thousands of neurons simultaneously.

Multielectrode array

Morphology

We use intracellular injections of fluorescent dyes (Lucifer Yellow, Alexa 594) in fixed tissue and in certain cases also injection of Biocytine during Patch Clamp recording.

Morphology

Behavior/Cognition

Most of our studies involve a thorough behavioral analysis. For this purpose, our laboratory uses several tests that allow us to evaluate a wide range of rodent behaviors (Barnes Maze, Fear Conditioning, Novel Object Location, and more).

Behavior cognition

Molecular manipulations

We use different strategies to manipulate the function of molecules in the brain, including pharmacology and gene transfer with viral vectors or plasmids in vitro and in vivo. We also use several lines of transgenic mice.

Molecular manipulations

Imaging

We are using super-resolution confocal imaging.

Imaging