We use a multielectrode array to record the activity of thousands of neurons simultaneously.
We use super-resolution confocal imaging and state-of-the-art software of image analysis, such as Imaris, Neurolucida and Neuroinfo.
Most of our studies involve a thorough behavioral analysis. For this purpose, our laboratory uses several tests that allow us to evaluate a wide range of rodent behaviors (Barnes Maze, Fear Conditioning, Novel Object Location, and more).
Tachykinin receptor 3 (TACR3) is a member of the tachykinin receptor family and falls within the rhodopsin subfamily. As a G protein-coupled receptor, it responds to neurokinin B (NKB), its high-affinity ligand. Dysfunctional TACR3 has been associated with pubertal failure and anxiety, yet the mechanisms underlying this remain unclear. Hence,...
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Synaptic impairment might precede neuronal degeneration in Parkinson’s disease. However, the intimate mechanisms altering synaptic function by the accumulation of presynaptic α-synuclein in striatal dopaminergic terminals before dopaminergic death occurs, have not been elucidated. Our aim is to unravel the sequence of synaptic functional and structural changes preceding the symptomatic...
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The real-time live fluorescent monitoring of surface AMPA receptors (AMPARs) could open new opportunities for drug discovery and phenotypic screening concerning neuropsychiatric disorders. We have developed FORTIS, a tool based on pH sensitivity capable of detecting subtle changes in surface AMPARs at a neuronal population level. The expression of SEP-GluA1...
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